1. I want this to be addressed in the introduction: • Defining the problem. Why is this important?

1. I want this to be addressed in the introduction:
• Defining the problem. Why is this important?
• Research question: We want to find out whether or not there is a relationship between depression and vitamin D and if there is, how much does vitamin D affects the level depression?

I want the introduction part to be written from these articles:
• Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367: 1747–57.
• World Health Organization. Mental Health Gap Action Programme: Scaling Up Care for Mental, Neurological, and Substance Use Disorders. WHO, 2008.
• Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 2010; 167: 1305–20.
• Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29: 21–30.
• Vitamin D, a neuroimmunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009; 34 (suppl 1): S265–77.

• Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch Intern Med 2009; 169: 626–32.
• Vitamin D Status of Canadians as Measured in the 2007 to 2009 Canadian Health Measures Survey. Health Reports 82-003-XPE: 8. Statistics Canada, 2010.
• Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006; 14: 1032–40.

• Association of vitamin D levels with incident depression among a general cardiovascular population. Am Heart J 2010; 159: 1037–43.
• itamin D deficiency and insufficiency in the Georgia Older Americans Nutrition Program. J Nutr Elder 2008; 27: 29–46.
• Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among US adults without physician-diagnosed diabetes: NHANES, 2003–2006. Diabetes Care 2010; 33: 344–7.






2. I want this in the search strategy:
o Which databases and why? which keywords?
o inclusion and exclusion criterias.

o flow-diagram (to show how the articles were selected)

Here are the inclusion/exclusion criteria which were used in step two in the flow diagram to exclude 5 studies:
• The study population (both cases and control groups) has to be D vitamin deprived and has depression.
• D vitamin supplementation: how much, how often, for how long?
• Adult population (+18 years)

Here are what we used as a database: cochrane controlled trials register.
theses databses have to be mentioned (we thought of using them but did not decide to use them as we only wanted Randomised controlled trials to be included, and the cochrane controlled trials register do offer only RCT that exist in all the other databses) PUBMED, EMBASE, GOOGLE SCHOLAR, WEB OF SCIENCE, CLINICALTRIALSREGISTER.EU and clinicaltrials.gov.

Here are ours search keywords: Vitamin D, Depression, Randomized controlled trials.

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