How this could be considered a negative feedback mechanism

Q1. The control center for body temperature regulation is in a region of the brain known as the hypothalamus. while the body is fighting an infection, the hypothalamus alters its control of body temperature, allowing temperature to climb higher than the normal value of about 38 degrees C. Explain how this could be considered a negative feedback mechanism.

Q2. Consider the HIV enzyme called protease. The amino acid residues at the active site are highly hydrophobic. In designing a drug that would bind to the active site and jam it, researchers must use which type of molecule?