Determine is uniquely expressed in a tumor cell

Which one of the following would you first need to determine is uniquely expressed in a tumor cell in order to change a “blocking” monoclonal antibody like Herceptin or Cetuximab into a chemotherapeutic “smart bomb” to target just that cell?

 A. An overexpressed tumor-specific transcription factor (e.g., c-myc).
 B. 

A tumor-specific protein kinase (e.g., BRAFV600E).

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 C. A tumor-specific absence of a tumor suppressor like NF1 or p53.
 D. 

A tumor-specific G protein (e.g., RasD).

 E. A tumor-specific integral plasma membrane protein.

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